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Article

Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Mar 2010

Allaman Igor, Gavillet Mathilde, Bélanger Mireille, Laroche Thierry, Viertl David, Lashuel Hilal A, Magistretti Pierre J

Abstract excerpt

Amyloid-beta (Abeta) peptides play a key role in the pathogenesis of Alzheimer's disease and exert various toxic effects on neurons; however, relatively little is known about their influence on glial cells. Astrocytes play a pivotal role in brain homeostasis, contributing to the regulation of local energy metabolism and oxidative stress defense, two aspects of importance for neuronal viability and function. In...

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Identifiers

PMID: 20203192
DOI: 10.1523/JNEUROSCI.5098-09.2010
PMCID: PMC6634099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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