Article

APP-KI mice do not display the hallmark age-dependent cognitive decline of amyloid diseases

2024-05-26

Abstract excerpt

APP knock-in (KI) mice serve as an exciting new model system to understand amyloid beta (Aβ) pathology, overcoming many of the limitations of previous overexpression-based model systems. The APP SAA mouse model (containing the humanized APP with three familial Alzheimer’s disease mutations) and the APP WT control are the first commercially available APP KI mice within the United States. While APP SAA mice have...

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Identifiers and source

Literature Corpus work: 4731adac-da1f-5691-8d8e-b604eae0f141
DOI: 10.1101/2024.05.24.595745

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