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Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice.

Neurobiology of disease - 15 Oct 2023

Medina-Vera Dina, Zambrana-Infantes Emma N, López-Gambero Antonio J, Verheul-Campos Julia, Santín Luis J, Baixeras Elena, Suarez Juan, Pavon Francisco J, Rosell-Valle Cristina, de Fonseca Fernando Rodríguez

Abstract excerpt

The amyloid cascade hypothesis is widely accepted as an explanation for the neuropathological changes in Alzheimer's disease (AD). However, the role of amyloid-beta (Aβ) as the sole cause of these changes is being questioned. Using the 5xFAD mouse model of AD, we investigated various factors contributing to neuropathology, including genetic load (heterozygous (HTZ) versus homozygous (HZ) condition), behavioural...

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PMID: 37717663
DOI: 10.1016/j.nbd.2023.106295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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