Article

Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming

2021-09-02

Abstract excerpt

Cellular senescence is an irreversible growth arrest with a highly dynamic secretome, termed the senescence-associated secretory phenotype (SASP). Senescence has been implicated in somatic reprogramming to pluripotency. The cell-intrinsic proliferation arrest is a barrier for reprogramming, whereas the SASP facilitates the cell fate conversion in nonsenescent cells. However, the mechanisms by which reprogramming-i...

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Literature Corpus work: 514eaabf-8e74-5733-a1b4-e7f1920e9583
DOI: 10.1101/2021.09.01.458621

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