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Article

Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming.

Cell reports - 12 Jul 2022

von Joest Mathieu, Chen Cheng, Douché Thibaut, Chantrel Jeremy, Chiche Aurélie, Gianetto Quentin Giai, Matondo Mariette, Li Han

Abstract excerpt

Cellular senescence is an irreversible growth arrest with a dynamic secretome, termed the senescence-associated secretory phenotype (SASP). Senescence is a cell-intrinsic barrier for reprogramming, whereas the SASP facilitates cell fate conversion in non-senescent cells. However, the mechanisms by which reprogramming-induced senescence regulates cell plasticity are not well understood. Here, we investigate how...

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PMID: 35830812
DOI: 10.1016/j.celrep.2022.111074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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