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Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses

1 Dec 2023

Abstract excerpt

Patient-derived organoids (PDOs) can model personalized therapy responses; however, current screening technologies cannot reveal drug response mechanisms or how tumor microenvironment cells alter therapeutic performance. To address this, we developed a highly multiplexed mass cytometry platform to measure post-translational modification (PTM) signaling, DNA damage, cell-cycle activity, and apoptosis in >2,500...

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PMID: 38065081
DOI: 10.1016/j.cell.2023.11.005

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