Article

Spatially Organized IGF1-mTOR Signaling Controls Human Forebrain Progenitor Fate Through Coordinated Transcriptional and Translational Programs

2025-05-12

Abstract excerpt

The specification and maintenance of human forebrain neural progenitor cells (NPCs) depend on both intrinsic gene networks and spatially localized niche signals, but the interplay between these cues remains incompletely understood. Here, we identify a spatially organized, paracrine IGF1 signaling architecture that regulates human FOXG1⁺ NPCs through multilayered transcriptional and translational control. Using a p...

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Literature Corpus work: 2f401e5c-a626-5a82-9f5b-55990095ae4a
DOI: 10.1101/2025.05.08.652851

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Spatially Organized IGF1-mTOR Signaling Controls Human Forebrain Progenitor Fate Through Coordinated Transcriptional and Translational ProgramsDOI 10.1101/2025.05.08.652851Read

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