Article

Genetically distinct microenvironment determines cancer survival and response to therapy in mice

2026-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Genetic uniqueness of the tumor microenvironment significantly influences cancer growth, survival, and response to therapy, independent of the cancer cell’s intrinsic properties or the adaptive immune system. Using genetically distinct Rag1-/- mouse models, this study shows that different strains exhibit varied tumor growth kinetics and survival outcomes when xenografted with identical leukemic...

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Literature Corpus work: 46bc1976-8d41-5872-9574-b2bda90da2bd
DOI: 10.64898/2026.07.10.737486

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