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Article

Building a healthy mouse model ecosystem to interrogate cancer biology.

Disease models & mechanisms - 1 Sept 2022

Devlin Ryan, Roberts Ed

Abstract excerpt

In a recent study, Sargent et al. characterise several novel Rag1-/- mouse strains and demonstrate that genetic background strongly influences xenograft development and phenotype. Here, we discuss this work within the broader context of cancer mouse modelling. We argue that new technologies will enable insights into how specific models align with human disease states and that this knowledge can be used to develop...

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Identifiers

PMID: 36098988
DOI: 10.1242/dmm.049795
PMCID: PMC9509886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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