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Investigating Tumor Heterogeneity in Mouse Models

6 Nov 2019

Abstract excerpt

Cancer arises from a single cell through a series of acquired mutations and epigenetic alterations. Tumors gradually develop into a complex tissue comprised of phenotypically heterogeneous cancer cell populations, as well as noncancer cells that make up the tumor microenvironment. The phenotype, or state, of each cancer and stromal cell is influenced by a plethora of cell-intrinsic and cell-extrinsic factors. The...

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PMID: 34164589
DOI: 10.1146/annurev-cancerbio-030419-033413

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