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Article

The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer

9 Nov 2023

Abstract excerpt

PURPOSE: The gastric adenocarcinoma (GC) represents the third cause of cancer-related mortality worldwide, and available therapeutic options remain sub-optimal. The Fibroblast growth factor receptors (FGFRs) are oncogenic transmembrane tyrosine kinase receptors. FGFR inhibitors have been approved for the treatment of various cancers and a STAT3-dependent regulation of FGFR4 has been documented in the H.pylori...

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PMID: 37945798
DOI: 10.1007/s13402-023-00893-8

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