Article

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition

2024-06-12

Abstract excerpt

<h4>Background</h4> The incidence of Barrett esophagus (BE) and Gastroesophageal Adenocarcinoma (GEAC) correlates with obesity and a diet rich in fat. Bile acids (BA) support fat digestion and undergo microbial metabolization in the gut. The farnesoid X receptor (FXR) is an important modulator of the BA homeostasis. The capacity of inhibiting cancer-related processes when activated, make FXR an appealing therapeu...

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Literature Corpus work: 983eb9d5-bd87-5415-88c1-fc434eb9536e
DOI: 10.1101/2024.06.11.598405

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