Article

Dysregulated dsRNA sensor signaling and viral infection during onset of pediatric autoimmune interferonopathy

2026-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Juvenile dermatomyositis (JDM) is characterized by a type I interferon (IFN-I) signature associated with disease activity. We previously identified a link between SARS-CoV-2 infection and the onset or relapse of JDM. Here, we show that newly diagnosed JDM patients display an overexpression of IFIH1 (encoding MDA5 protein) at baseline, coupled with an altered response to dsRNA stimulation at pro...

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Literature Corpus work: 1e19129e-43ed-514c-b782-cc1409e0edc8
DOI: 10.64898/2026.05.27.728148

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