Transcriptomes of peripheral blood mononuclear cells from juvenile dermatomyositis patients show elevated inflammation even when clinically inactive

Abstract excerpt

In juvenile dermatomyositis (JDM), the most common pediatric inflammatory myopathy, weakness is accompanied by a characteristic rash that often becomes chronic, and is associated with vascular damage. We hoped to understand the molecular underpinnings of JDM, particularly in untreated disease, which would facilitate the identification of novel mechanisms and clinical targets that might disrupt disease progression....

Topics

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• Autoantibodies
• Autoimmunity
• Celiac Disease Research and Management
• Dendritic Cells
• Dermatomyositis
• Histocompatibility Antigens Class I
• Immune System
• Inflammatory Myopathies and Dermatomyositis

Identifiers and source

Literature Corpus work

9cf893aa-4bf5-57f0-9dea-3c67deafbaca

DOI

10.1101/2021.05.07.443007