Article

Multi-modal single-cell sequencing identifies cellular immunophenotypes associated with juvenile dermatomyositis disease activity

2021-09-23

Abstract excerpt

<h4>ABSTRACT</h4> Juvenile dermatomyositis (JDM) is a rare autoimmune condition with insufficient biomarkers and treatments, in part, due to incomplete knowledge of the cell types mediating disease. We investigated immunophenotypes and cell-specific genes associated with disease activity using multiplexed RNA and protein single-cell sequencing applied to PBMCs from 4 treatment-naïve JDM (TN-JDM) subjects at baseli...

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Literature Corpus work: 2839e51f-73c4-50c2-9b31-3657d7bcb631
DOI: 10.1101/2021.09.18.21263581

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