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A distinct immune landscape in anti-synthetase syndrome profiled by a single-cell genomic study

24 Oct 2024

Abstract excerpt

Objectives The objective of this study was to profile the transcriptional profiles of peripheral blood mononuclear cells (PBMCs) and their immune repertoires affected by anti-synthetase syndrome (ASS) at the single-cell level. Methods We performed single-cell RNA sequencing (scRNA-seq) analysis of PBMCs and bulk RNA sequencing for patients with ASS (N=3) and patients with anti-melanoma differentiation-associated...

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PMID: 39512337
DOI: 10.3389/fimmu.2024.1436114

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