Article

RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell-type

2021-07-12

Abstract excerpt

<h4>SUMMARY</h4> The human terminal uridyl transferases TUT4 and TUT7 (TUT4/7) catalyse additions of uridines at the 3′ end of RNAs such as the precursors of the tumour suppressor miRNA let-7, upon recruitment by the oncoprotein LIN28A. Consequently, let-7 family miRNAs are downregulated. Disruption of this TUT4/7 activity inhibits tumorigenesis and hence targeting TUT4/7 can be a potential anti-cancer therapy. I...

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Literature Corpus work: 4669c60d-0233-59e8-bcf3-646cee7c7195
DOI: 10.1101/2021.07.12.451846

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