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Article

Unraveling the genetic links between depression and type 2 diabetes.

Progress in neuro-psychopharmacology & biological psychiatry - 20 Mar 2025

Baranova Ancha, Liu Dongming, Chandhoke Vikas, Cao Hongbao, Zhang Fuquan

Abstract excerpt

BACKGROUND: Type 2 diabetes (T2D) is a chronic metabolic disorder that has high comorbidity with mental disorders. The genetic relationships between T2D and depression are far from being well understood. METHODS: We performed genetic correlation, polygenic overlap, Mendelian randomization (MR) analyses, cross-trait meta-analysis, and Bayesian colocalization analysis to assess genetic relationships between T2D and...

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Share to Diabetes Mellitus, Type 2
Share to FADS1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TCF4 gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Major Depressive Disorder

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Source

Identifiers

PMID: 39837361
DOI: 10.1016/j.pnpbp.2025.111258

Genes

CCDC92
DENND1A
ERI1
FADS1
MAD1L1
NEGR1
NUCKS1
PM20D1
SCYL1
TCF4
THUMPD3
TNKS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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