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Bi-directional Mendelian randomization and multi-phenotype GWAS show causality and shared pathophysiology between depression and type 2 diabetes

2022-12-06

Abstract excerpt

<h4>OBJECTIVE</h4> Depression is a common co-morbidity of type 2 diabetes. However, the causality and underlying mechanisms remain unclear. <h4>RESEARCH DESIGN AND METHODS</h4> We applied bi-directional Mendelian randomization (MR) to assess causality between type 2 diabetes and self-reported depression. Using the UK biobank, we performed 1) GWAS, separately, and 2) multi-phenotype GWAS (MP-GWAS) of type 2 diabete...

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Literature Corpus work: 1da8d13a-d83e-53e8-b220-e794bcd02a98
DOI: 10.1101/2022.12.06.22283143

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