Article

Systems genetics analysis of human body fat distribution genes identifies Wnt signaling and mitochondrial activity in adipocytes

2023-09-06

Abstract excerpt

<h4>BACKGROUND</h4> Excess fat in the abdomen is a sexually dimorphic risk factor for cardio-metabolic disease. The relative storage between abdominal and lower-body subcutaneous adipose tissue depots is approximated by the waist-to-hip ratio adjusted for body mass index (WHRadjBMI). Genome-wide association studies (GWAS) identified 346 loci near 495 genes associated with WHRadjBMI. Most of these genes have unkno...

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Literature Corpus work: 46656cc9-992b-55d5-a018-e326a1be2f23
DOI: 10.1101/2023.09.06.556534

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