Article
RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.
Nature communications - 3 Jun 2020
Loh Nellie Y, Minchin James E N, Pinnick Katherine E, Verma Manu, Todorčević Marijana, Denton Nathan, Moustafa Julia El-Sayed, Kemp John P, Gregson Celia L, Evans David M, Neville Matt J, Small Kerrin S, McCarthy Mark I, Mahajan Anubha, Rawls John F, Karpe Fredrik, Christodoulides Constantinos
Abstract excerpt
Fat distribution is an independent cardiometabolic risk factor. However, its molecular and cellular underpinnings remain obscure. Here we demonstrate that two independent GWAS signals at RSPO3, which are associated with increased body mass index-adjusted waist-to-hip ratio, act to specifically increase RSPO3 expression in subcutaneous adipocytes. These variants are also associated with reduced lower-body fat,...
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