Back to search

Article

Integration of single cell omics with biobank data discovers<i>trans</i>effects of<i>SREBF1</i>abdominal obesity risk variants on adipocyte expression of more than 100 genes

2024-11-23

Abstract excerpt

Given the fast-increasing prevalence of obesity and its comorbidities, it would be critical to improve our understanding of the cell-type level differences between the two key human adipose tissue depots, subcutaneous (SAT) and visceral adipose tissue (VAT), in their depot-specific contributions to cardiometabolic health. We integrated cell-type level RNA- and ATAC-seq data from human SAT and VAT biopsies and cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0306bea5-4b51-5412-85e7-f837a1a7c6c1
DOI
10.1101/2024.11.22.24317804
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integration of single cell omics with biobank data discovers<i>trans</i>effects of<i>SREBF1</i>abdominal obesity risk variants on adipocyte expression of more than 100 genesDOI 10.1101/2024.11.22.24317804
Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging.Semantic proximity
Lessons from single cell omics: admixed American ancestry and sex confer cardiometabolic disease risk in Mexicans.Semantic proximity
Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMISemantic proximity
Integrative functional genomics and fine-mapping identify regulatory mechanisms of multivariate obesity GWAS and its cardiometabolic implications.Semantic proximity
An integrated single cell and spatial transcriptomic map of human white adipose tissueSemantic proximity
Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiersSemantic proximity
Cell-Type Heterogeneity in Adipose Tissue Is Associated with Complex Traits and Reveals Disease-Relevant Cell-Specific eQTLsSemantic proximity
Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactionsSemantic proximity
Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity.Semantic proximity
Identification of TBX15 as an adipose master trans regulator of abdominal obesity genesSemantic proximity
Adiposity-Dependent Regulatory Effects on Multi-tissue Transcriptomes.Semantic proximity
Methylome and transcriptome maps of human visceral and subcutaneous adipocytes reveal key epigenetic differences at developmental genesSemantic proximity
Select a neighboring publication to make it the new centre.