Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.

Hypertension (Dallas, Tex. : 1979) - 1 Feb 2015

Zhang Min, Hagenmueller Marco, Riffel Johannes H, Kreusser Michael M, Bernhold Elmar, Fan Jingjing, Katus Hugo A, Backs Johannes, Hardt Stefan E

Abstract excerpt

Activation of Wnt signaling results in maladaptive cardiac remodeling and cardiomyopathy. Recently, calcium/calmodulin-dependent protein kinase II (CaMKII) was reported to be a pivotal participant in myocardial remodeling. Because CaMKII was suggested as a downstream target of noncanonical Wnt signaling, we aimed to elucidate the role of CaMKII in dishevelled-1-induced cardiomyopathy and the mechanisms underlying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzylamines
Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dishevelled Proteins

Share to Histone Deacetylases

Share to Hypertrophy, Left Ventricular

Share to MEF2 Transcription Factors

Share to Ventricular Dysfunction, Left

Share to Ventricular Remodeling

Source

Identifiers

PMID: 25489064
DOI: 10.1161/HYPERTENSIONAHA.114.04467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.PMID 25489064Read ↗

Nuclear CaMKII Isoforms as Regulators of Transcription: From Developmental to Pathological PersistenceSemantic proximity Read ↗

Wnt Signaling Inhibitors as Therapeutic Approach in Ischemic Heart DiseaseSemantic proximity Read ↗

Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II in Notch Signaling and Cardiovascular Development.Semantic proximity Read ↗

Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failureSemantic proximity Read ↗

Transcription Factor 7-like 2 Mediates Canonical Wnt/β-Catenin Signaling and c-Myc Upregulation in Heart FailureSemantic proximity Read ↗

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy.Semantic proximity Read ↗

Inhibition of Jumonji demethylases reprograms severe dilated cardiomyopathy and prolongs survivalSemantic proximity Read ↗

α-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction, Resulting in Cardiomyopathy and Susceptibility to Wall RuptureSemantic proximity Read ↗

Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitorsSemantic proximity Read ↗

Myoferlin Regulates Wnt/β-Catenin Signaling-Mediated Skeletal Muscle Development by Stabilizing Dishevelled-2 Against AutophagySemantic proximity Read ↗

Phosphoproteomics Study Based on In Vivo Inhibition Reveals Sites of Calmodulin‐Dependent Protein Kinase II Regulation in the HeartSemantic proximity Read ↗

Differential Wnt-mediated programming and arrhythmogenesis in right versus left ventricles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.