Article

DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains

2025-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Hereditary spastic paraplegia subtype SPG54 is a genetic neurological disorder caused by mutations in the DDHD2 gene. Excessive lipid droplet accumulation is observed in the brains of SPG54 patients and DDHD2 knockout mice, consistent with DDHD2’s reported neutral lipase activity. Here, we find recombinant human DDHD2 preferentially hydrolyzes diacylglycerol (DAG) over phospholipids, with a slig...

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Literature Corpus work: 2320e859-e4e9-5126-a885-a8602bd3f5ae
DOI: 10.1101/2025.09.22.677815

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