Article

Impaired DNA damage response and inflammatory signalling underpins hematopoietic stem cell defects in <i>Gata2</i> haploinsufficiency

2024-08-21

Abstract excerpt

Clinical GATA2 deficiency syndromes arise from germline haploinsufficiency inducing mutations in GATA2 , resulting in immunodeficiency that evolves to myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML). How GATA2 haploinsufficiency disrupts the function and transcriptional network of hematopoietic stem/progenitors (HSCs/HSPCs) to facilitate the shift from immunodeficiency to pre-leukemia is poorly char...

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Literature Corpus work: 3df2958d-c9e9-50d9-ab57-48bae6386643
DOI: 10.1101/2024.08.20.608056

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