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Article

Allergic airway reactions rewired by PI3Kδ mutation.

The Journal of experimental medicine - 6 Apr 2026

Kane Lawrence P

Abstract excerpt

In this issue of JEM, Golec et al. (https://doi.org/10.1084/jem.20252154) report that a mutation of PI-3 kinase underlying activated PI3K δ syndrome (APDS) impairs type 2 immunity. Surprisingly, mice with this mutation have disordered responses to allergic insults, with enhanced production of IFN-γ and a decrease in Th2 cytokines.

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Identifiers

PMID: 41718715
DOI: 10.1084/jem.20252509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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