Article

Adjusting for medication use in GWAS and its impact on Mendelian randomization analyses: an example of systolic blood pressure in UK Biobank

2026-01-11

Abstract excerpt

Medication use is common in large-scale population cohorts, and can modify phenotypic traits of interest. This can potentially bias effect estimates in genome-wide association studies (GWAS) and impact downstream analyses such as mendelian randomization (MR). The best approach to account for medication use in GWAS is unclear. In this study, we compared seven different methods of adjusting for antihypertensive use...

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Literature Corpus work: 4646be07-6fa1-524e-9ef2-5b9c0628f6b3
DOI: 10.64898/2026.01.09.26343783

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