Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estimating the Population Benefits of Blood Pressure Lowering: A Wide-Angled Mendelian Randomization Study in UK Biobank.

Journal of the American Heart Association - 7 Sept 2021

Higgins Hannah, Mason Amy M, Larsson Susanna C, Gill Dipender, Langenberg Claudia, Burgess Stephen

Abstract excerpt

Background The causal relevance of elevated blood pressure for several cardiovascular diseases (CVDs) is uncertain, as is the population impact of blood pressure lowering. This study systematically assesses evidence of causality for various CVDs in a 2-sample Mendelian randomization framework, and estimates the potential reduction in the prevalence of these diseases attributable to long-term population shifts in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Specimen Banks
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular Diseases

Share to Causality

Share to Genome-Wide Association Study

Share to Hypertension

Share to Mendelian Randomization Analysis

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 34459231
DOI: 10.1161/JAHA.121.021098
PMCID: PMC8649307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estimating the Population Benefits of Blood Pressure Lowering: A Wide-Angled Mendelian Randomization Study in UK Biobank.PMID 34459231Read ↗

Estimating the Population Benefits of Blood Pressure Lowering: A Wide-Angled Mendelian Randomization Study in UK BiobankSemantic proximity Read ↗

Blood Pressure and Risk of Cardiovascular Disease in UK Biobank: A Mendelian Randomization Study.Semantic proximity Read ↗

Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization StudySemantic proximity Read ↗

The total and direct effects of systolic and diastolic blood pressure on cardiovascular disease and longevity using Mendelian randomisation.Semantic proximity Read ↗

A factorial Mendelian randomization study to systematically prioritize genetic targets for the treatment of cardiovascular diseaseSemantic proximity Read ↗

Genetically predicted blood pressure, antihypertensive drugs and risk of heart failure: a Mendelian randomization study.Semantic proximity Read ↗

Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization AnalysisSemantic proximity Read ↗

Genetically Predicted Differences in Systolic Blood Pressure and Risk of Cardiovascular and Noncardiovascular Diseases: A Mendelian Randomization Study in Chinese AdultsSemantic proximity Read ↗

Genetic susceptibility, elevated blood pressure, and risk of atrial fibrillation: a Mendelian randomization study.Semantic proximity Read ↗

Evaluating genetically-predicted causal effects of lipoprotein(a) in human diseases: a phenome-wide Mendelian randomization studySemantic proximity Read ↗

Identification of Circulating Proteins Associated With Blood Pressure Using Mendelian Randomization.Semantic proximity Read ↗

Blood Pressure and Risk of Atrial Fibrillation: A Mendelian Randomization StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.