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Article

Genetic susceptibility, elevated blood pressure, and risk of atrial fibrillation: a Mendelian randomization study.

Genome medicine - 4 Mar 2021

Nazarzadeh Milad, Pinho-Gomes Ana-Catarina, Bidel Zeinab, Canoy Dexter, Dehghan Abbas, Smith Byrne Karl, Bennett Derrick A, Smith George Davey, Rahimi Kazem

Abstract excerpt

BACKGROUND: Whether elevated blood pressure (BP) is a modifiable risk factor for atrial fibrillation (AF) is not established. We tested (1) whether the association between BP and risk of AF is causal, (2) whether it varies according to individual's genetic susceptibility for AF, and (3) the extent to which specific BP-lowering drugs are expected to reduce this risk. METHODS: First, causality of association was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33663581
DOI: 10.1186/s13073-021-00849-3
PMCID: PMC7934395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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