Article

Goliath clades and <i>in vivo</i> tracking of clonal dynamics show three phases of UV-induced skin carcinogenesis

2024-12-29

Abstract excerpt

<h4>SUMMARY</h4> While the genetic paradigm of cancer etiology has proven powerful, it remains incomplete as evidenced by the widening spectrum of non-cancer cell-autonomous “hallmarks” of cancer. Studies have demonstrated the commonplace presence of high oncogenic mutational burdens in homeostatically-stable epithelia. Hence, the presence of driver mutations alone does not result in cancer. Here, we reveal addit...

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Literature Corpus work: 463ced9e-5b7f-57a0-82b9-2887d9b1b313
DOI: 10.1101/2024.12.28.623235

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Goliath clades and <i>in vivo</i> tracking of clonal dynamics show three phases of UV-induced skin carcinogenesisDOI 10.1101/2024.12.28.623235Read

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