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Article

Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates

30 Aug 2016

Abstract excerpt

Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage...

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PMID: 27574101
DOI: 10.1038/ncomms12601

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