Article

Plasticity of squamous differentiation drives drug resistance in HNSCC

2026-03-11

Abstract excerpt

A critical hallmark of carcinogenesis is the ability of cancer cells to evade the loss of self-renewal normally imposed by terminal differentiation. However, therapies directly attempting to promote differentiation have shown limited efficacy in solid tumours and the cellular mechanisms behind cancer cell persistence are poorly understood. Here we established a patient-derived orthotopic head and neck squamous cel...

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Literature Corpus work: 46124f10-0fb7-519d-a1ff-db36b8393fe4
DOI: 10.64898/2026.03.09.710514

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