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Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer

23 May 2024

Abstract excerpt

The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. Employing alterations in Rb1/Trp53/Myc (RPM), we establish a genetically engineered mouse model of high-grade metastatic ONB exhibiting a NEUROD1+ immature neuronal phenotype. We demonstrate that globose basal cells (GBCs) are a permissive cell of...

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PMID: 38788720
DOI: 10.1016/j.ccell.2024.05.003

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