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Genomic and Single-Cell Analyses Characterize Patient-Derived Tumor Organoids to Enable Personalized Therapy for Head and Neck Squamous Cell Carcinoma

22 Apr 2025

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) remains a significant health burden because of tumor heterogeneity and treatment resistance, emphasizing the need for improved biological understanding and tailored therapies. In this study, we enrolled 31 patients with HNSCC for the establishment of patient-derived tumor organoids (PDO), which faithfully maintained the genomic features and histopathologic traits of...

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Cancer Cells and Metastasis
Cancer Genomics and Diagnostics
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40261963
DOI: 10.1158/0008-5472.can-24-2850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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