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Determination of α-Synuclein Protein Interactions by μMap Photo-proximity Labeling

2025-09-18

Abstract excerpt

<h4>ABSTRACT</h4> Fibrillar aggregates of the natively disordered protein α-synuclein (αS) are hallmarks of Parkinson’s disease and related neurodegenerative disorders termed synucleinopathies. Here, we used micromap (µMap) photo-proximity labeling to determine the interactomes of αS monomers and fibrils in mouse brain lysate to better understand both the loss of healthy function and gain of toxic function aspect...

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Literature Corpus work
45f37f85-419d-5eba-8f4c-5c92943cc47c
DOI
10.1101/2025.09.18.674129
Open publication

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Determination of α-Synuclein Protein Interactions by μMap Photo-proximity LabelingDOI 10.1101/2025.09.18.674129
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