Article

Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion

2024-02-07

Abstract excerpt

<title>Abstract</title> <p>The neuropathology of α-Synucleinopathies (αSP) is characterized by the spread of subcellular inclusions containing fibrils made of stacked-up α-Synuclein (α-Syn) monomers. The repetitive amyloid fold adopted by α-Syn has now been characterized at the atomic scale. However, the direct observation of amyloid α-Syn using routine immuno-histological procedures remains an issue. In particul...

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Literature Corpus work: f61080b9-70f0-5b06-8145-c652a4a17195
DOI: 10.21203/rs.3.rs-3921168/v1

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