Article

<i>Doublesex-</i> mediated regulation of insulin signaling drives sex-specific body growth

2026-06-29

Abstract excerpt

Most animals develop sex-biased body sizes driven by sexually divergent plasticity in nutrient-dependent growth. Prior work in Drosophila , implicated the sex-determination gene transformer ( tra ) in regulation of sex differences in body size. However, tra does not widely mediate sex determination across insects. Thus, the unifying molecular pathway governing female-biased sexual size dimorphism (SSD) remains...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 45dc47b2-7660-58f0-b953-0634a2e31a10
DOI: 10.64898/2026.06.26.734866

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Doublesex-</i> mediated regulation of insulin signaling drives sex-specific body growthDOI 10.64898/2026.06.26.734866Read

An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology.Semantic proximity Read

Fourfold lifespan extension in <i>C. elegans</i> daf-2 mutant malesSemantic proximity Read

Two Doublesex1 mutants revealed a tunable gene network underlying intersexuality in Daphnia magna.Semantic proximity Read

A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila.Semantic proximity Read

PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.Semantic proximity Read

An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans.Semantic proximity Read

Molecular evolution and functional characterization of Drosophila insulin-like peptides.Semantic proximity Read

Sex differences in the regulation and function of cellular immunity in <i>Drosophila</i>Semantic proximity Read

Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs.Semantic proximity Read

A conserved somatic sex determination cascade instructs trait-specific sexual dimorphism in horned dung beetlesSemantic proximity Read

Drosophila insulin‐like peptides: from expression to functions – a reviewSemantic proximity Read

Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons.Semantic proximity Read