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Article

Molecular evolution and functional characterization of Drosophila insulin-like peptides.

PLoS genetics - 26 Feb 2010

Grönke Sebastian, Clarke David-Francis, Broughton Susan, Andrews T Daniel, Partridge Linda

Abstract excerpt

Multicellular animals match costly activities, such as growth and reproduction, to the environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway plays key roles in growth, metabolism, stress resistance, reproduction, and longevity in diverse organisms including mammals. Invertebrate genomes often contain multiple genes encoding insulin-like ligands, including seven Drosophila...

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Identifiers

PMID: 20195512
DOI: 10.1371/journal.pgen.1000857
PMCID: PMC2829060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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