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Article

Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs.

PloS one - 1 Jan 2008

Broughton Susan, Alic Nazif, Slack Cathy, Bass Timothy, Ikeya Tomoatsu, Vinti Giovanna, Tommasi Anna Maria, Driege Yasmine, Hafen Ernst, Partridge Linda

Abstract excerpt

The insulin/IGF-like signalling (IIS) pathway has diverse functions in all multicellular organisms, including determination of lifespan. The seven insulin-like peptides (DILPs) in Drosophila are expressed in a stage- and tissue-specific manner. Partial ablation of the median neurosecretory cells (mNSCs) in the brain, which produce three DILPs, extends lifespan, reduces fecundity, alters lipid and carbohydrate...

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Identifiers

PMID: 19005568
DOI: 10.1371/journal.pone.0003721
PMCID: PMC2579582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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