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Article

Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2008

Clements Jason, Hens Korneel, Francis Carmen, Schellens Ann, Callaerts Patrick

Abstract excerpt

Insulin/insulin-like growth factor (IGF) signaling constitutes an evolutionarily conserved pathway that controls growth, energy homeostasis, and longevity. In Drosophila melanogaster, key components of this pathway are the insulin-like peptides (Dilps). The major source of Dilps is a cluster of large neurons in the brain, the insulin-producing cells (IPCs). The genetic control of IPC development and function is...

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Identifiers

PMID: 18852455
DOI: 10.1073/pnas.0708330105
PMCID: PMC2566994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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