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Article

Engineering multivalent Fc display for FcγR blockade

2024-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Autoimmune diseases, driven by Fcγ receptor (FcγR) activation through autoantibody immune complexes (IC), present a complex therapeutic challenge of achieving pharmacological blockade of FcγR without triggering receptor activation. The assembly of ICs into polydisperse, higher-order structures is required for FcγR activation. However, engineered multimeric, monodisperse Fc assemblies have been r...

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Literature Corpus work
45d8fe2a-3bbf-5ccc-9ccc-f4a1d223c378
DOI
10.1101/2024.01.20.576357
Open publication

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Engineering multivalent Fc display for FcγR blockadeDOI 10.1101/2024.01.20.576357
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