Article

Translational Opportunity of Engineered IFNγ-eEVs Through Targeted Inhibition of JAK/STAT1 Signaling, Mimicking IVIg Therapy

2026-05-03

Abstract excerpt

<h4>ABSTRACT</h4> Immunoglobulin (Ig) replacement therapies (IgRT) including intravenous (IVIg) and subcutaneous (SCIg), are pooled IgG preparations widely used to restore humoral immunity and to suppress pathological inflammation in autoimmune and inflammatory disorders. Despite broad clinical use, the mechanisms underlying their immunomodulatory effects remain incompletely defined. Here, we identify extracellul...

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Literature Corpus work: 05a9c80d-7c0e-5995-a570-0d6f9c82b28c
DOI: 10.64898/2026.04.29.721601

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