Article

Reverse engineering of a pathogenic antibody reveals the molecular mechanism of vaccine-induced immune thrombotic thrombocytopenia

2023-07-01

Abstract excerpt

The massive COVID-19 vaccine roll-out campaign illuminated a range of rare side effects, the most dangerous of which – vaccine-induced immune thrombotic thrombocytopenia (VITT) – is caused by adenoviral (Ad)-vectored vaccines. VITT occurrence had been linked to production of pathogenic antibodies that recognize an endogenous chemokine, platelet factor 4 (PF4). Mass spectrometry (MS)-based evaluation of the ensembl...

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Literature Corpus work: f80111ba-1e0d-553e-b954-70f113f493c2
DOI: 10.1101/2023.06.30.547300

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