Article

Transposable elements as evolutionary substrates of protein disorder in the human proteome

2026-06-14

Abstract excerpt

Intrinsically disordered regions (IDRs) are central contributors to protein function, evolution and human disease, yet the evolutionary routes that seed new disordered segments within pre-existing proteins are still poorly understood. Sequence insertions provide a powerful mechanism for disorder expansion, but the genomic donors of inserted IDR and its long-term conformational fate remain largely unknown. Transpos...

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Literature Corpus work: 45c986a7-6815-5ba9-b4d3-6c3e1909ad89
DOI: 10.64898/2026.06.12.731867

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