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Article

Transposable elements shape the human proteome landscape via formation of cis-acting upstream open reading frames.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2018

Kitano Shohei, Kurasawa Hikaru, Aizawa Yasunori

Abstract excerpt

Transposons are major drivers of mammalian genome evolution. To obtain new insights into the contribution of transposons to the regulation of protein translation, we here examined how transposons affected the genesis and function of upstream open reading frames (uORFs), which serve as cis-acting elements to regulate translation from annotated ORFs (anORFs) located downstream of the uORFs in eukaryotic mRNAs....

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PMID: 29446201
DOI: 10.1111/gtc.12567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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