Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary Forces and Codon Bias in Different Flavors of Intrinsic Disorder in the Human Proteome.

Journal of molecular evolution - 1 Mar 2020

Forcelloni Sergio, Giansanti Andrea

Abstract excerpt

In this study, we perform a systematic analysis of evolutionary forces (i.e., mutational bias and natural selection) that shape the codon usage bias of human genes encoding proteins characterized by different flavors of intrinsic disorder. Well-structured proteins are expected to be more under control by purifying natural selection than intrinsically disordered proteins because one or few mutations (even...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Composition
Share to Computational Biology
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Mutation

Share to Selection, Genetic

Source

Identifiers

PMID: 31820049
DOI: 10.1007/s00239-019-09921-4

Genes

GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary Forces and Codon Bias in Different Flavors of Intrinsic Disorder in the Human Proteome.PMID 31820049Read ↗

Evolutionary forces on different flavors of intrinsic disorder in the human proteomeSemantic proximity Read ↗

New perspectives into the evolutionary pressures acting on the Human intrinsically disordered proteinsSemantic proximity Read ↗

Disease mutations in disordered regions--exception to the rule?Semantic proximity Read ↗

Is there a biological cost of protein disorder? Analysis of cancer-associated mutations.Semantic proximity Read ↗

Conservation and coevolution determine evolvability of different classes of disordered residues in human intrinsically disordered proteins.Semantic proximity Read ↗

Characterization of intrinsically disordered regions in proteins informed by human genetic diversity.Semantic proximity Read ↗

Disentangling the CHAOS of intrinsic disorder in human proteinsSemantic proximity Read ↗

New classification of intrinsic disorder in the Human proteomeSemantic proximity Read ↗

Mutations in disordered proteins as early indicators of nucleic acid changes triggering speciationSemantic proximity Read ↗

Ancient evolutionary origin of intrinsically disordered cancer risk regionsSemantic proximity Read ↗

Structural and functional restraints on the occurrence of single amino acid variations in human proteins.Semantic proximity Read ↗

Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.