Evolutionary Forces and Codon Bias in Different Flavors of Intrinsic Disorder in the Human Proteome.

doi:10.1007/s00239-019-09921-4

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Article

Evolutionary Forces and Codon Bias in Different Flavors of Intrinsic Disorder in the Human Proteome.

Journal of molecular evolution - 1 Mar 2020

Forcelloni Sergio, Giansanti Andrea

Abstract excerpt

In this study, we perform a systematic analysis of evolutionary forces (i.e., mutational bias and natural selection) that shape the codon usage bias of human genes encoding proteins characterized by different flavors of intrinsic disorder. Well-structured proteins are expected to be more under co...

Topics

Base Composition
Codon Usage
Computational Biology
Evolution, Molecular
Humans
Intrinsically Disordered Proteins
Models, Genetic
Mutation
Proteome
Selection, Genetic

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