Article

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

2020-11-18

Abstract excerpt

Mechanical forces control cell behavior, including cancer progression. Cells sense forces through actomyosin and YAP, but what regulators of actin mechanotransduction play relevant roles in vivo remains unclear. Here we identify the Fascin1 F-actin bundling protein as a key factor sustaining YAP activation in response to ECM mechanical cues. This is relevant in the mouse liver, where Fascin1 regulates YAP-dependen...

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Identifiers and source

Literature Corpus work: 45b68552-217c-50d8-b6f4-b73cab669dfb
DOI: 10.1101/2020.11.18.388397

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