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Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation

22 Aug 2016

Abstract excerpt

Microtubules function in TGF-β signalling by facilitating the cytoplasmic trafficking of internalized receptors and the nucleocytoplasmic shuttling of Smads. However, nothing is known about whether actin filaments are required for these processes. Here we report that zebrafish actin-bundling protein fscn1a is highly expressed in mesendodermal precursors and its expression is directly regulated by the TGF-β...

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PMID: 27545838
DOI: 10.1038/ncomms12603

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