Article

ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma 

2021-01-04

Abstract excerpt

<h4>Background: </h4> Alpha actinins (ACTNs) are major cytoskeletal proteins and exhibit many non-muscle functions. Emerging evidence have uncovered the regulatory role of ACTNs in tumorigenesis, however, the expression pattern, biological functions, and underlying mechanism of ACTN1 in hepatocellular carcinoma (HCC) remain largely unexplored. <h4>Methods: </h4>: Immunohistochemical analysis of a HCC tissue microa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1c60932-2986-5db3-b46d-fb44be8e428b
DOI: 10.21203/rs.3.rs-72190/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma DOI 10.21203/rs.3.rs-72190/v2Read

Normal tissue adjacent to tumor expression profile analysis developed and validated a prognostic model based on Hippo‐related genes in hepatocellular carcinomaSemantic proximity Read

Piezo1 promoted hepatocellular carcinoma progression and EMT through activating TGF-β signaling by recruiting Rab5cSemantic proximity Read

Integrated Analysis of the Anoikis‐Related Signature Identifies Rac Family Small GTPase 3 as a Novel Tumor‐Promoter Gene in Hepatocellular CarcinomaSemantic proximity Read

ALKBH5 promotes Liver hepatocellular carcinoma cell proliferation, migration and invasion by regulating TTI1 expressionSemantic proximity Read

Quantitative proteomics analysis of FFPE tumor samples reveals the influences of NET-1 siRNA nanoparticles and sonodynamic therapy on tetraspanin protein involved in HCCSemantic proximity Read

Piezo1 Promoted Hepatocellular Carcinoma Progression and EMT Through Activating TGF-β Signaling by Recruiting Rab5cSemantic proximity Read

Proteogenomic characterization of hepatocellular carcinomaSemantic proximity Read

TGFβ-induced long non-coding RNA LINC00313 activates Wnt signalling and promotes cholangiocarcinoma progressionSemantic proximity Read

TWF1 induces autophagy and accelerates malignant phenotype in lung adenocarcinoma via inhibiting the cAMP signaling pathway.Semantic proximity Read

Talin1 promotes HCC progression by regulating NRG1/PI3K/AKT axisSemantic proximity Read

Lamin B1 is a potential therapeutic target and prognostic biomarker for hepatocellular carcinomaSemantic proximity Read

AFP deletion leads to anti-tumorigenic but pro-metastatic roles in liver cancers with concomitant CTNNB1 mutations.Semantic proximity Read