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Article

Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS

16 Mar 2017

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders that exist on a symptomological spectrum and share both genetic underpinnings and pathophysiological hallmarks. Functional abnormality of TAR DNA-binding protein 43 (TDP-43), an aggregation-prone RNA and DNA binding protein, is observed in the vast majority of both familial and sporadic...

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PMID: 28301478
DOI: 10.1371/journal.pgen.1006635

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